Brain 17 Vienna
Inactivation of MGMT gene by promoter methylation
unmethylated MGMT promotor
Chemo- resistance
Transcription/translation
MGMT gene
MGMT promoter
active
„Non-Responder“
MGMT promotor methylation
Chemosen- sitivity
Transcription/translation
MGMT gene
CH 3 CH 3 MGMT promoter CH 3 CH 3 CH 3
inactive
„Responder“
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