Brain 17 Vienna
Brain mets: a particular challenge?
=> Crizotinib: very limited CNS penetrance (< 1%)
Costa et al. J Clin Oncol 2011
• Novel ALK inhibitors: ceritinib and alectinib which are both active against ALK-positive NSCLC • Ceritinib concentration in the CNS may reach approximately 13% of systemic levels in preclinical models
Shaw et al. New Engl J Med 2014 Gadgeel et al. Lancet Oncol 2014 Kim et al. ASCO 2014
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