Brain 17 Vienna

How large should be the margin? Which technique should be used?

• Several series analyzed the pattern of failure after radiotherapy for LGG • In the NCCTG 86-72-51 trial 92% of the failures occurred in the treatment field, 3% within 2cm and 5% more than 2 cm • Radiosurgery remains investigational but margins may be reduced • Protons may reduce the integral dose and can result in reduction of late toxicity