Brain 17 Vienna

RT RCT- summary

• Radiotherapy is effective at a dose of 45 to 54 Gy • Higher dose could be dangerous (late toxicity seen more often in the HD arm of the NCCTG trial) • Early postoperative radiotherapy determined significant improvement in progression free survival from 3.4 to 5.3 years in the EORTC 22845 trial • Deferring radiotherapy did not impact adversely on overall survival, but the effect on PFS and Freedom from seizure may substancially impact on quality of life • Those trials were carried out between the 80s and the 90s, with quite simple radiotherapy techniques also including Cobalt