Brain 17 Vienna

EORTC/NCIC-CTG/TROG/MRC-CTU (EORTC 22033-26033) in patients with a high risk low-grade glioma Participating groups: EORTC ROG and BTG, NCI-CTG, TROG, MRC-CTU

Radiotherapy (standard arm): 50.4 Gy (28 x 1.8 Gy) conformal techniques

Genetic testing

Registration

Random

TMZ (experimental arm): 75 mg/m2 daily x 21 days, q 28 days until progression or for max. 12 cycles

Stratification: 1p deletion contrast on MRI, age and PS, institute, contrast enhancement MRI, age: <40 vs ≥ 40 yrs, WHO PS 0 /1 versus 2

Accrual: 2005 – 2012

707 patients registered 477 randomized

Baumert, Hegi,…Stupp, Lancet Oncol 17, 1521–1532, 2016