Brain 17 Vienna
07.11.2017
4. Which molecular markers do you routinely test for neuropathological work-up of diffuse gliomas?
4. Which molecular markers do you routinely test for neuropathological work-up of diffuse gliomas?
Eu Af SA As NA Au
IDH1 IDH2 1p 19q MGMT
§ § §
High Low Income
Yes No
High Low
Yes Sometimes No
Yes No
ATRX TERT
§
Other
%
0 25 50 75 100
Yes No
64 %
Limited access §
*GrossDomestic Product
Woehreretal,ClinNeuropathol2017
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50
4. Which molecular markers do you routinely test for neuropathological work-up of diffuse gliomas?
5. Which molecular techniques and platforms do you currently use?
10+ responses
Gene panel sequencing Targeted gene sequencing Methylation-specificPCR Pyrosequencing Fluorescence in situhybridization Multiplex lig.-depend. probe amplification Methylation array
High Low Income
High Low Yes Sometimes No
Yes No
0 25 50 75 100 %
Yes No
High within-country heterogeneity
Woehreretal,ClinNeuropathol2017
Woehreretal,ClinNeuropathol2017
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52
5. Which molecular techniques and platforms do you currently use?
5. Which molecular techniques and platforms do you currently use?
Eu Af SA As NA Au
§
High Low Income
High Low Income
High Low
High Low
Yes Sometimes No
Yes Sometimes No
Yes No
Yes No
≈ Mutually exclusive
Variable
combinations
Yes No
High within-country heterogeneity (might indicate centralization of diagnostic services)
> 50 %
No access §
Woehreretal,ClinNeuropathol2017
Woehreretal,ClinNeuropathol2017
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54
9
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