Brain Tumours

Chordoma Chondrosarcoma

Chordoma: Radiation

• The primary role of radiation therapy following maximal surgical resection is to improve local control • There have been no randomized studies investigating optimal dose • Initial results in the 1960s and 1970s suggest an improvement in symptomatic response and local control with increasing dose • Used antiquated techniques and often included multiple sites in their reports • In 1970 Pearlman and Friedman: Decrease in local failure with ↑ dose

Dose

Rates of Failure

<40 Gy (n=47)

85%

40 – 60 Gy (n=18)

60%

60-80 Gy (n=8)

43%

>80 Gy (n=2)

0%

03/01/13