Brain Tumours

Chordoma Chondrosarcoma

Ares et al . IJROBP 2009;75(4):1111-8

Prognostic Factors Significant for Local Control in CHORODMA • Residual tumor volume >25 c.c. • Brainstem compression ------------------------------------------------------------------------------------------------------- Radiation-induced Late Toxicity (CTCAE v3.0) • Asymptomatic MRI white matter changes (G1) = 5 patients • High grade late toxicity = 4 patients (all diagnosed with chordoma) - optic pathway: G4 (1 patient) – unilateral blindness G3 (1 patient) – unilateral visual deficit, steroid dependent - neurologic: G3 (2 patients) – symptomatic brain necrosis -------------------------------------------------------------------------------------------------------- Actuarial 5-year freedom from high-grade toxicity: 94%

03/01/13