Brain Tumours

How to choose the best AED

1. Carbamazepine 2. Gabapentin 3. Lacosamide 4. Lamotrigine 5. Levetiracetam 6. Oxcarbazepine 7. Perampanel 8. Phenobarbital 9. Primidon 10. Phenytoin 11. Pregabalin 12. Topiramate 13. Valproic acid 14. Zonisamide

CBZ GBP LAC LTG LEV OXC PER PRM PHT PGB TPM VPA ZON Pb

„time to treatment failure“: LTG > CBZ, GBP und TPM Time from randomization (years)

Marson et al., Lancet 2007

„seizure control“ LEV = CBZ

Brodie et al., Neurology 2007