Brain Tumours

IMAGING TUMOR PROLIFERATION [(18)F]-FLT-PET fluorothymidine

• Uptake of FLT correlates with Thymidine kinase-1 activity expressed during DNA synthesis • High correlation with Ki-67 expression (Yamamoto J Nucl Med 2012) • Might be superior to MET for tumour grading • The kinetics of FLT uptake are closely related to prognosis, early efficacy of treatment and to outcome (Wardak Clin Cancer Research 2011) • PITFALLS : • less sensitivity than MET for low grade gliomas • CANNOT PREDICT GRADE

Astrocytoma Grade II

Oligodendroglioma Grade I

Anaplastic Oligodendroglioma Grade II

GBM Grade IV