Brain Tumours

Brain necrosis Introduction

• Coagulation necrosis • Vascular Thickening • Peri-vascular fibrosis • Infiltartion of chr inflammatory cells Therory 1. Vascular hypothesis : lesions of small to medium vessels, necrosis is secondary to ischemia. 2. Glial hypothesis : irradiation damage glial cells (oligodendrocytic +++) leading to white matter cavitation and demylenisation 3. Immunologic hypothesis : radiation necrosis and vascular change in response to Ag release from damaged glial cells

03/01/13