Brain Tumours

Conclusions (late toxicity)

1. CNS toxicity is dose dependant and volume dependant 2. Metrics/dose constraints are based on studies with varying parameters (target volume, sample size, radiation modality, brain region, etc…) 3. Brain necrosis after (very) high-dose RT frequent: 10-15% @ 5 years 4. Is usually symptomatic and requires therapy 5. Risk factors: Gender?, DVH metrics 6. Pituitary dysfunction: very common for GHD but not treated in the majority of cases 7. GH replacement for cancer patient: no evidence of tumor recurrence 8. Constraints mean dose to cochlea to < 43-45 Gy 9. Constraint dose to 60 and 55-56 Gy to the ON and OC, respectively. 10. Correlation between hippocampal irradiation and neuro-cognitive toxicity 11. Hippocampal avoidance in young patients with LGG or benigh tumors?

03/01/13