Brain Tumours

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Inactivation of MGMT gene by promoter methylation

unmethylated MGMT promotor

Chemo- resistance

Transcription/translation

MGMT gene

MGMT promotor

active

„Non-Responder“

MGMT promotor methylation

Chemosen- sitivity

Transcription/translation

MGMT gene

CH 3 CH 3 MGMT promotor CH 3 CH 3 CH 3

inactive

„Responder“

Made with