Brain Tumours

What is PCV?

Procarbazine

Lomustine (CCNU)

Vincristine

p.o.

p.o.

i.v.

Alkylating agent

Alkylating nitrosourea compound

Vinca alkoid

Breaking of DNA strands

Mitotic inhibitor – inhibiting the assembly of microtubule structures

Breaking of DNA strands

Good penetration trough blood-brain-barrier

Good penetration trough blood-brain-barrier

Moderate to low penetration trough blood-brain-barrier

Molecular weight: 233 Da

Molecular weight: 923 Da

Molecular weight: 258 Da

Dose limiting side effects: Hematotoxicity

Dose limiting side effects: Hematotoxicity

Dose limiting side effects: Peripheral neuropathy

High (>90%) emetogenic