Brain Tumours

PCV toxicities EORTC 26951 vs RTOG 9402

Toxicities (Grade 3/4)

EORTC 26951

RTOG 9402

Hematologic, any

46% 32% 21%

56% 42% 37%

Neutropenia

Thrombocytopenia

Anemia

7% 2% 6%

5% 8% 8%

Peripheral neuropathy

Nausea/vomiting

Toxicity leading to treatment stop

38%

20%