Brain Tumours

WBRT MAY NEGATIVELY IMPACT HEALTH-RELATED QUALI TY OF LIFE (HRQL) IN BRAIN METASTASIS

• Increasing interest for HRQL as an endpoint for treatment comparisons in many cancer types, especially in advanced stages ( Bottomley et al, Eur J Cancer 2005 ) • After PCI for SCLC significant, but reversible, short-term (3 months) negative impact on selected HRQL scales, such as fatigue, hair loss, or cognitive functioning ( Slotman et al, JCO 2009 ). • After PCI for NSCLC significant decline in memory at 1 year ( Sun et al, JCO 2011 ) • No data available so far regarding the impact of adjuvant WBRT on HRQL of patients with brain metastases.