Brain Tumours

Hippocampal Injury from Cranial RT

• Preclinical evidence – 97% reduction in hippocampal neurogenesis 2 months after cranial RT – Up-regulation of microglial differentiation and activation

Blue: GCL,

Green: SGZ

Black: Cranial RT

White: Control

Monje et al, Nat Med 2002; Gondi et al, JCO 2010.