Brain Tumours

‘Stupp’ regime

• radiotherapy to enhancing tumour or resection cavity plus 2-3 cm margin • daily temozolomide 75 mg/m 2 during radiotherapy • standard radiotherapy dose (60 Gy 30#) • 6 cycles of adjuvant temozolomide (5/28 days) – 1st cycle 150 mg/m 2 – escalate to 200 mg/m 2 if tolerated – about 50% of patients completed 6 cycles