Brain Tumours

48 year old patient with MGMT unmethylated GBM, >90% resection, PS=1 post-op. Completes RT-TMZ. She attends for 1 st cycle adjuvant TMZ; PS now 2: fatigue, poor short term memory. Your recommendation is: A. Commence adjuvant TMZ as protocol B. Defer adjuvant TMZ until PS = 1 or better C. Commence adjuvant TMZ but reconsider after cycle 1 D. Decision to proceed with adjuvant TMZ depends on result of MRI scan after RT/TMZ E. Advise patient no benefit from adjuvant TMZ