Brain Tumours

Classical

Proneural

Mesenchymal NF1 del YKL-40 expr Met expr

Neural

Cr 7 Ampl Cr 10 loss p16 deletion

IDH1 mut p53 mut PDGFRA mut

Neuron markers expression

grade III/IV

Grade IV

No necrosis

Necrosis Inflammation

Younger (<40y)

older

The molecular background

better OS

poor OS

Secondary GBM

same histology and grade BUT different prognosis

Verhaak R. et al 2010 and Phillips et al. 2006