Brain Tumours

Intracranial germ cell tumours (GCT)

General strategy in diagnosis and management Europ. Consensus SIOP CNS GCT Germinoma If tumour markers are negative or slightly elevated, a histological diagnosis is mandatory Secreting germ cell tumours If tumor markers αFP and/or βHCG are elevated (αFP > 25 ng/ml; βHCG > 50 IU/L) and imaging shows a characteristic lesion, a secreting germ cell tumour is diagnosed and treatment should be started with chemotherapy (without histological confirmation)