Brain Tumours

SIOP CNS GCT 96 / germinoma

Design of protocol

Option A : radiotherapy of craniospinal axis : 24 Gy (5 x 1.6 Gy / week) followed by RT to tumour site : 16 Gy (5 x 1.6 Gy / week) Total tumour dose : 40 Gy

Option B : 2 courses Carbo PEI

(600mg/m2 d1 -- VP16 150mg/m2 d1-3/22-24 – Ifosfam. 1800mg/m2 d22-26) followed by RT to tumour site : 40 Gy (5 x 1.6 Gy / week)