Brain Tumours

SIOP CNS GCT II / new study / germinoma

SIOP CNS GCT II

Underlying philosophy: Convert macroscopic to subclinical disease by using chemotherapy before RT Dose reduction from 40 to 24 Gy (primary tumour site) (Japanese data, : overall tumor-free rate 92.9% (52 of 56 pat.) Med.f-up, 2.1 years, 1 relapse outside RT area. Matsutani et al., 1998 Dose reduction to non-target brain (dose reduction to functionally relevant areas) Reduction of risk for late effects