Brain Tumours

Non - germinomatous GCT

Protocols Europe / North America / Asia

Japan (Asia)

Treatment Europe

North America (ACNS 1123)

(SIOP GCT II)

RT volume Local (M0)

Whole ventricular / boost (M0) CSI / boost (M+)

CSI / boost (M0- M+)

CSI/boost (M+)

30 Gy CSI (M+) 54 Gy local (M0) 4 x PEI (cispl / etop / ifosph) HD chx in high risk pat. before RT

30.6 (WV-RT or CSI) 23.6 Gy boost

Japan (M0-M+) 30 Gy CSI 24-30 Gy (boost) Japan 5 x ICE ( ifosph/, cisplatin /etop.) before RT

Dose prescription

Chx. protocol

6 x carbopl. / etoposide / ifosfamide before RT&