Brain Tumours

The G-PCNSL-SG1 trial

Randomisation WBRT yes (A1, B1) or no (A2, B2)

n=526

6 x HD-MTX plus ifosfamide (biweekly) 3 x 8 mg dexamethasone/die for 10 days in cycle 1

CR

PR, SD, PD

Arm A

Arm B

n=56

n=96

n=98

n=68

WBRT 4-7 weeks after CR A1

Observation

WBRT

4 x HD-Ara-C 4 x 3 g/m 2 in 48 h 21 d cycles B2

A2

B1