Brain Tumours

IELSG-32 trial

PCNSL [≤ 65 years, PS 0-3] or [65-70 years, PS ≤2] ®

4x Rituximab 375 mg/m 2 D-5/0 MTX 3.5 g/m 2 D1

4x MTX 3.5 g/m 2 D1

4x Rituximab 375 mg/m 2 D-5/0 MTX 3.5 g/m 2 D1 AraC 2 g/m 2 x 2/d, D2-3 x 3 weeks

AraC 2 g/m 2 x 2/d, D2-3 x 3 weeks

AraC 2 g/m 2 x 2/d, D2-3 Thiotepa 30 mg/m 2 D4 x 3 weeks

Response assessment

CR – PR - SD

PD – Tox  SC Harvest

®

WBRT 40 Gy ± Boost 9 Gy

WBRT 36 Gy ± Boost 9 Gy

BCNU 400 mg/m 2 D1 Thiotepa 5 mg/kg x 2/d; D2-3 + APBSCT