Brain Tumours

Medulloblastoma History of Chemotherapy Clinical Trials:

Chemo better for high-risk subgroups Standard dose RT (35-36 Gy established)

 1970s-1980s: - Adjuvant chemotherapy - SIOP I,CCSG 942

Intensive sandwich CT better than RT alone (PNET 3) Immediate RT better than delayed Cisplatin, VCR,CCNU

 1980s-1990s: - Pre-RT (Sandwich CT) - SIOP II, SIOP/UKCCSG PNET 3 - Pre vs post RT chemotherapy : HIT 91,CCG 921 - CCG 9862 adjuvant chemotherapy (CVP)

chemo standard and reduced dose RT (23.4 Gy) established