Brain Tumours

Milan HART Study

- 1998-2007 - 33 pts (M1 9, M2 6, M3 17, M4 1) - High dose chemotherapy approach - HART: CSI 39 Gy; 1.3 Gy bid

posterior fossa boost up to 60 Gy; 1.5 Gy bid

- 7 pts aged < 10 yrs who achieved CT after chemo received a lower dose to the neuraxis (31.2 Gy)

- Median 82 months follow-up

- 5 yr EFS 70% - 5 yr PFS 72% - 5 yr OS 73%

Gandola L. et al, JCO, 27, 2009