Brain Tumours

A Phase 1 Study of AZD6244 in Children with Recurrent or Refractory Low Grade Gliomas: A Pediatric Brain Tumor Consortium Report Responses •8 subjects with radiographic partial response •6 of 8 PRs observed in subjects treated at MTD ( 25 mg/m2/dose) • Objective response rate at MTD = 6/24 (25%) •5 of 8 subjects with PR had sufficient tissue for BRAF studies; 4 of these 5 had a BRAF mutation (n=1) or fusion (n=3)