Brain Tumours

Baseline Patient Characteristics

Dose cohort

3 mg/kg (n = 3)

3.75 mg/kg (n = 10)

4.50 mg/kg (n = 8)

5.25 mg/kg (n = 6)

Total (N = 27)

Mean age (years) Range

8.7 4 − 14

11.6 3 − 17

6.5 1 − 17

7.7 3 − 12

8.9 1 − 17

Sex

Female Male

1 2

5 5

3 5

3 3

12 15

3 HGG

5 HGG; 3 LGG 1 LCH; 1 PTC

6 LGG; 1 LCH 1 NB

6 LGG

8 HGG; 15 LGG; 2 LCH; 1 PTC; 1 NB

Tumor type

- HGG histology - LGG histology

2 AA; 1 AG 2 GBM; 1 AGG

1 AA; 1 APXA 1 JPA; 1GG; 1 PMA

4 JPA; 2 GG

1 PXA; 1 JPA; 1 GG; 3 LGG

AA , anaplastic astrocytoma; AG , anaplastic glioma; AGG , anaplastic ganglioglioma; APXA , anaplastic pleomorphic xanthoastrocytoma ; GBM , gliobastoma multiforme; GG , ganglioglioma; HGG , high grade glioma; JPA , juvenile pilocytic astrocytoma; LCH , Langerhans cell histiocytosis; LGG , low grade glioma; NB , neuroblastoma; PMA , pilomyxoid astrocytoma; PTC , papillary thyroid carcinoma; PXA , pleomorphic xanthoastrocytoma. 111