Brain Tumours

Adverse Events

• Most common AE class – Skin and subcutaneous tissue disorders 25 (93%) patients • Most common AE terms – Pyrexia 14 (52%) patients – Fatigue 12 (44%) patients – Vomiting 12 (44%) patients – Headache 11 (41%) patients • Dose-limiting toxicity (1 event) – Grade 3 transient maculopapular rash at 4.5 mg/kg/day dose • Patient remains on study at reduced dose (3.75 mg/kg/day)

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