Brain Tumours

LDE225 induced tumor regression is associated with Gli1 suppression in tumor Ptch +/- p53 -/- mouse allograft 150

100

50

0

16hr

24hr

8hr

Vehicle 4hr Gli1 expression of Vehicle (%)

LDE225

1000 1500 2000 2500 3000 Tumor volume (mm 3 ) mean ± SEM

150

Vehicle

5mg/kg

100

50

0

Vehicle 4hr Gli1 expression of Vehicle (%)

8hr

16hr

24hr

LDE225

8 10 12 14 16 18 20 22 0 500

10 mg/kg 20 mg/kg

150

100

Days Post Implantation

50

0

Vehicle 4hr Gli1 expression of Vehicle (%)

8hr

16hr

24hr

LD E22

LDE225