Brain Tumours

LDE225: responses in medulloblastoma

Patient A (200 mg QD )  Prior surgery, radiation, 4 chemotherapy regimens and autologous BMT  Partial response maintained for 4 months

Cycle 2

Pre-treatment

Patient B (1500 mg QD)  Prior surgery, radiation, 4 chemotherapy regimens and autologous BMT  Partial response by PET scan maintained more than 7months LDE225C2201 Pivotal Medulloblastoma | Confidential | Business Use Only

Pre-treatment

Cycle 2