CPB Budapest 2017

Improvement in Chemoradiation Without Brachytherapy

366 resectable tumors (T2-3N0-1M0)

Randomization RT vs. CRT followed by resection 41.4 Gy (1.8) + paclitaxel 50 mg/m2 + carboplatin AUC = 2 mg/ml/min

92% R0 resections Pathologic CR 29% Median Survival:

RT 24 mths vs. CRT 49.4 mths.

3 y OS:

RT 44% vs. CRT 58%

Van Hagen, New Engl J Med 2012;366:2074-2084