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Which patients benefit from irradiation and concomitant chemotherapy?

Local Control

Surv. w/o colostomy

Disease spec. Survival

Survival

RT only

55 % p = 0,02 68 %

40 % p = 0,002 72 %

55 % NS 57 %

EORTC

Radio- chemo RT only

39 % p <0,0001 61 %

61 % p = 0,02 72 %

58 % p = 0,25 65 %

UKCCCR

Radio- chemo

Ref. : Bartelink : J Clin Oncol 1997;5:2040–2049 : UKCCCR : Lancet 1996;348:1049–1054