CPB Ljubljana 2018 course book

EORTC 22881/10882 “boost” Poortmans et al (actualized 2008) median FU 10.8y

Electrons Photons Interstitial

Number with boost Median boost dose Median boosted cc 10 y. Local recurrence

1635 (63%)

753 (28%)

225 (9%)

Total 2661

16 Gy

16 Gy

15 Gy

144cc

288cc

60cc

No boost 9.8% No boost 1.6%

6.3% 5.3% 3.7%

Severe fibrosis

3.8% 5.3% 5.3%