CPB Ljubljana 2018 course book

Budapest phase III APBI

2007

National Institute of Oncology Budapest (1998-2004) • 258 pat. T1 N0-1 mic G1-2, no lobular, EIC-, margins-, • FU 66m. - 130 WBI 50 Gy - 128 APBI - 88 BT HDR 36.4 Gy (5.2 Gyx7) - 40 electrons 50 Gy • Cosmesis good/excellent 63% vs 77% (p=0.009)

Same control, better cosmesis

( 81% HDR vs 70% e- )

Update at 7 years

.

3,3% vs 5,1% (p=0,53)

• Local failures:

• Regional failure: 1,7% vs 1,6% (p= 0,99) • CSS

93,9% vs 96,2% (p=0,45) 89,4% vs 91,7% (p=0,44)

• OS

Polgár C, Fodor J, Major T, Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma--5-year results of a randomized trial.Int J Radiat Oncol Biol Phys . 2007 Nov 1;69(3):694-702.