Cervix BT - 2016

Effect of uncertainties on observed dose response relationships Comparison of model dose response curve (based on published curves, see previous slides), and simulated „observed“ dose response curves assuming different systematic and random uncertainties.

random dosimetric uncertainty e.g. rectum D 2cm³

systematic dosimetric uncertainty e.g. rectum D 2cm³

(±10, ±20, ±30 % / fx)

(+3,+5,+10,+15 % / fx)

Simulations of patient cohort with total dose = 45Gy EBRT + 4 fx BT (equal PD for each fx), model based on Georg er al. 2012, IJROBP

Courtesy Nicole Nesvacil, MUW

“Can reduction of uncertainties in cervix cancer brachytherapy potentially improve clinical outcome?” Nesvacil et al. 2016, submitted to R&O