Cervix BT - 2016

Physician assessed morbidity Common Toxicity Criteria of AE

Combined information is translated by physician into medical terms and grades

Analytic outcomes (lab / imaging)

objective subjective

Physician assessed objective symptoms

CTCAE v4. Proctitis G2

Symptoms e.g., rectal discomfort, passing blood or mucus; medical intervention indicated; limiting instrumental activities of daily life Depends on the interpretation of the physician Translation problems may be assumed!

Patient reported subjective symptoms Patient reported objective symptoms

Patient reported impact of symptoms on ADL Patient reported complex multidimensional concepts

clinical decision / medical intervention