Course book Advanced Treatment Planning 2018

Dose accumulation – normal tissues

• Standard dose plans are a good approximation to delivered dose • Dose differences of 10-15% can be detected (eg in trials)

• Further individualisation possible with measurement (estimate) of accumulated dose - D A

• Our research programme was trying to do just this ➢ VoxTox – linking dose at the voxel level with toxicity ➢ Consider rectal toxicity ...