Course book Advanced Treatment Planning 2018

Individual variation in normal tissue sensitivity

• Variation in response harder to observe with mega-voltage beams because of skin sparing

• Could be exploited: ➢

To avoid toxicity in sensitive patients ▪ ≤ 5% of patients ➢ To dose escalate resistant patients ▪

40% of patients - dose escalate up to ~15%

• Other methods to measure normal tissue response are needed, to produce more & better dose response data