Course book Advanced Treatment Planning 2018

Dosimetry, Biology and Clinic

• Dosimetry: planning related data ➢ Dose distribution ➢ Fractionation ➢ Volume irradiated ➢ Hot-Cold spots ➢ DVH (and related indicators) • Biology: OAR ➢

V-values D-values Mean dose

Maximum dose Minimum dose

Dose/Response models (Lyman, Log-Logistic…)

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Volume effect

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Reliability of radiobiological prediction

• Clinic: factors that can affect the outcome ➢

Patient related: Age, Smoke, HPV status (for H&N), comorbidities… ➢ Treatment related: chemo, hormonal therapy… ➢ Prognosis, treatment aim (definitive, local control, palliation)