Course book Advanced Treatment Planning 2018

The Volume Effect in OAR

1

Parallel

V

   

   

a

reference

VD

VD

(

)

=

(

)



irradiated

reference

V

irradiated

20

Relative Tolerance Dose

10

5

1

0.1

0.5

0.5

1/ a

Fraction of Irradiated Volume

Serial

0

1

Adapted and redrawn from: Marks LB, et al. Use of normal tissue complication probability models in the clinic. Int. J. Radiat. Oncol. Biol. Phys. 2010 (76-3): S10-S19.