Course book Advanced Treatment Planning 2018

How to consider the volume effect in dose-response models?

2

x

DD

−

1

(

)

−

t

50 

2

NTCP

dx e t

=

=



2





•

Probit : Lyman

50

D

−

2



50

1

j     =  = 1

   

a

a j j Dv

EUD

1

NTCP

=

•

Logistic (log dose ): Niemierko

4



50

  

  

D

1

+

D

50