Course book Advanced Treatment Planning 2018

Reliability of radiobiological evaluation • Solution 1: different populations, different parameters to be used in dose-response model (Lyman)

1.0

Sequential CRT

Concomitant CRT

TD

46 (42 – 50)

TD

36 (34 – 56)

50

50

0.5

2.7 (1.25 – 5)

0.95 (0.71 – 1.11)

 50

 50

a

3.4 (2.4 – 5)

a

11.1 (1.3 – 14.3)

NTCP [*100 %]

0

0

40

80

120

Dose [Gy]

J Zhu et al. Analysis of acute radiation-induced esophagitis in non-small-cell lung cancer patients using the Lyman NTCP model. Radiother Oncol (2010) 449–454.