Course book Advanced Treatment Planning 2018

Multivariate NTCP model: use of logistic regression for fitting different covariates (in addition to dose): Parameters for clinical outcome: Salivary glands

e 1 − +

 ˆ

x x  22

NTCP

=

X

nn x + + + 



 + =



 ˆ

0

11

X

1

NTCP

X  ˆ

Beetz I et al. Development of NTCP models for head and neck cancer patients treated with three-dimensional conformal radiotherapy for xerostomia and sticky saliva: The role of dosimetric and clinical factors. Radiother. Oncol. Volume 105, Issue 1, Pages 86–93.