Course book Advanced Treatment Planning 2018

Parameters for clinical outcome: Small bowel

Small bowel toxicity in patients with GYN tumors undergone or not to abdominal surgery: 1) 95 patients with GYN malignancies 2) 34 patients after surgery, 61 patients without prior surgery 3) Use of LASSO for modeling logistic regression over Vdose parameters

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   

   + = V TV

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50

NTCP

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TV 50 = tolerance volume corresponding to 50% incidence of complications V = volume of small bowel receiving a given dose level  = normalized slope of the volume response curve

TF Lee et al. The Different Dose-Volume Effects of Normal Tissue Complication Probability Using LASSO for Acute Small-Bowel Toxicity during Radiotherapy in

Gynecological Patients with or without Prior Abdominal Surgery. BioMed Research International Volume 2014, Article ID 143020.