Course book Advanced Treatment Planning 2018

Parameters for clinical outcome: Rectum

Dose-Volume limits for > G2 rectal toxicity with LQ corrected doses ( / = 3 Gy)

100

80

CTCAE G2 : Symptoms not interfering with ADL; medical intervention indicated RTOG G2 : Increase of 4-6 stools/day, or nocturnal stools, or moderate cramping

V50

60

V60

40

V65

Volume [%]

V70

V75

20

0

10

20

30

40

50

60

70

80

90

LQ equivalent dose in 2 Gy fractions (Gy)

Michalski JM et al. Radiation Dose-Volume effects in radiation-induced rectal injury. Int. J. Radiation Oncology Biol. Phys., Vol. 76, No. 3, Supplement, pp. S123–S129, 2010.