Course book Advanced Treatment Planning 2018

Normal tissue toxicities

• Toxicity largely relates to late normal tissue effects

➢

Tissue specific

• Some acute toxicities also important ➢

Especially applies to concurrent chemo-RT

• Very late effects of second malignancy ➢ Difficult to estimate reliably

➢ For IMRT, need to balance risk from larger irradiated volume against lower risk of organ damage ➢ Role for PBT in children