Course book Advanced Treatment Planning 2018

Parameters for clinical outcome: Rectum

• Dose-Volume histogram ( DVH ) against Dose-Wall Histogram ( DWH )

DWH better predicts Rectal Toxicity than DVH

The difference in model accuracy is not so high AvAUC DVH = 0,73 AvAUC DWH = 0,76

• Toxicity scored with a modified RTOG score • Endpoint G2 or higher within 2 years from the end of the treatment

Tucker SL et al. Comparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapy. Int J Radiat Oncol Biol Phys 2004;60:1589–601.